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- Title
Phorbol myristate acetate-induced Egr-1 expression is suppressed by phospholipase D isozymes in human glioma cells
- Authors
Ahn, Bong-Hyun; Park, Mi Hee; Lee, Young Han; Min, Do Sik
- Abstract
Abstract: Early growth response-1 (Egr-1) is involved in the regulation of cell growth. Here, we found that overexpression of phospholipase D (PLD) isozymes decreased tumor promoter phorbol myristate acetate (PMA)-induced Egr-1 expression and transactivation in glioma cells. Suppression of PMA-induced Egr-1 was dependent on the expression level of PLD isozymes. Overexpression of catalytically inactive PLD, treatment with PA, and prevention of PA dephosphorylation by 1-propranolol significantly suppressed PMA-induced Egr-1 expression. PLD-induced suppression of Egr-1 was reversed by inhibition of phosphatidylinositol 3-kinase (PI3K). Taken together, these results suggest that elevated expression and activity of PLD attenuate PMA-induced Egr-1 expression via PI3K pathway.
- Subjects
PHOSPHOLIPASES; ISOENZYMES; TUMORS; GLIOMAS
- Publication
FEBS Letters, 2007, Vol 581, Issue 30, p5940
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2007.11.077