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- Title
Different functional classes of genes are characterized by different compositional properties
- Authors
D’Onofrio, Giuseppe; Ghosh, Tapash Chandra; Saccone, Salvatore
- Abstract
Abstract: A compositional analysis on a set of human genes classified in several functional classes was performed. We found out that the GC3, i.e. the GC level at the third codon positions, of the genes involved in cellular metabolism was significantly higher than those involved in information storage and processing. Analyses of human/Xenopus ortologous genes showed that: (i) the GC3 increment of the genes involved in cellular metabolism was significantly higher than those involved in information storage and processing; and (ii) a strong correlation between the GC3 and the corresponding GCi, i.e. the GC level of introns, was found in each functional class. The non-randomness of the GC increments favours the selective hypothesis of gene/genome evolution.
- Subjects
GENES; HEREDITY; MOLECULAR genetics; INTRONS
- Publication
FEBS Letters, 2007, Vol 581, Issue 30, p5819
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2007.11.052