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- Title
Identification of the TPO1 gene in yeast, and its human orthologue TETRAN, which cause resistance to NSAIDs
- Authors
Mima, Shinji; Ushijima, Hironori; Hwang, Hyun-Jung; Tsutsumi, Shinji; Makise, Masaki; Yamaguchi, Yoshihiro; Tsuchiya, Tomofusa; Mizushima, Hiroshi; Mizushima, Tohru
- Abstract
Abstract: Non-steroidal anti-inflammatory drugs (NSAIDs), such as indomethacin, have serious gastrointestinal side effects. Since their direct cytotoxicity was suggested to be involved in this side effect, we here tried to identify NSAID-resistant genes. We screened for Saccharomyces cerevisiae genes whose overexpression causes indomethacin resistance and identified the TPO1 gene, which encodes a major facilitator superfamily transporter. Its overexpression or deletion made yeast cells resistant or sensitive, respectively, to some NSAIDs. A BLAST search identified the possible human orthologue of Tpo1p, tetracycline transporter-like protein (TETRAN), whose overexpression in cultured human cells caused resistance to some NSAIDs, suggesting that TETRAN is an efflux pump for some NSAIDs.
- Subjects
DRUG side effects; PHARMACODYNAMICS; DRUG interactions; IATROGENIC diseases
- Publication
FEBS Letters, 2007, Vol 581, Issue 7, p1457
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2007.03.001