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- Title
Immune cell-induced synthesis of NO and reactive oxygen species in lymphoma cells causes their death by apoptosis
- Authors
Hu, De-En; Brindle, Kevin M.
- Abstract
Abstract: Induction of apoptosis in a lymphoma cell line using immune cell-conditioned medium, etoposide or an nitric oxide (NO) donor, resulted in the production of reactive oxygen species (ROS). Agents that inhibited NO production or scavenged ROS or species formed by reaction of NO with ROS, protected the cells from apoptosis. These data support the suggestion that immune rejection of an immunogenic derivative of this lymphoma in vivo involves the induced synthesis of both NO and ROS by the tumour cells.
- Subjects
REACTIVE oxygen species; PHOTOSYNTHETIC oxygen evolution; NITROGEN compounds; NONMETALS
- Publication
FEBS Letters, 2005, Vol 579, Issue 13, p2833
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2005.03.099