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- Title
High-Dose Vitamin D Supplementation is Necessary After Bariatric Surgery: A Prospective 2-Year Follow-up Study.
- Authors
Lanzarini, Enrique; Nogués, Xavier; Goday, Albert; Benaiges, David; Ramón, Marta; Villatoro, Montserrat; Pera, Manuel; Grande, Luis; Ramón, José
- Abstract
Background: We assessed the need of vitamin D supplementation to achieve normal 25-hydroxyvitamin D (25[OH]D) levels after bariatric surgery and whether there were differences between laparoscopy sleeve gastrectomy (LSG) and laparoscopic Roux-en-Y gastric bypass (LRYGB). Methods: A total of 164 morbid obese patients undergoing bariatric surgery from January 2008 to June 2011 were followed for 2 years. Serum levels of 25(OH)D and intact parathyroid hormone (iPTH) were measured preoperatively and at 3, 6, 9, 12, 18, and 24 months after operation. All patients received 400 IU/day of 25(OH)D. Patients received additional supplementation with 16,000 IU of vitamin D3 (calcifediol) every 2 weeks if 25(OH)D serum levels were <30 ng/mL (intervention group). Results: Ninety-six (58.5 %) patients underwent LSG and 68 (41.5 %) LRYGB. A total of 106 (64.6 %) patients received calcifediol supplementation (62 in the LSG group and 44 in the LRYGB group). Normal 25(OH)D levels at 24 months were recorded in 69 % of patients in the intervention group and in 48.3 % in the non-intervention group. At 24 months, mean 25(OH)D levels in the non-intervention group were significantly lower among LRYGB patients than among LSG patients ( P = 0.009). In the intervention group, normal 25(OH)D levels were achieved in 60 % of patients treated with LSG and in 22.2 % of those treated with LRYGB. Secondary hyperparathyroidism was presented in 49 (29.9 %) patients preoperatively but without significant differences in iPTH levels between the two surgical procedures. Conclusion: Patients undergoing bariatric surgery should receive high-dose vitamin D supplementation independently of the surgical technique.
- Subjects
PHYSIOLOGICAL effects of vitamin D; BARIATRIC surgery; MORBID obesity; LAPAROSCOPIC surgery; GASTRECTOMY; PARATHYROID hormone; FOLLOW-up studies (Medicine); PATIENTS
- Publication
Obesity Surgery, 2015, Vol 25, Issue 9, p1633
- ISSN
0960-8923
- Publication type
Article
- DOI
10.1007/s11695-015-1572-3