We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
DIAGNOSTIC AND THERAPEUTIC APPROACH TO SMALL BOWEL CARCINOID TUMOR. CASE REPORT.
- Authors
Pais, Raluca; Dadoun, F.; Zota, M. B.; Coldea, Lucica Agoston; Taïeb, D.; Barthet, M.; Dutour-Meyer, Anne; Dumitrascu, D.
- Abstract
Detecting the primary tumours in carcinoid malignancies is a critical challenge. We report the case of a 25 year old male patient with a typical clinical carcinoid syndrome. Metastatic carcinoid malignancy was easily diagnosed by very high plasma chromogranin, plasma serotonin and urinary 5-Hydroxy-Indol Acetic Acid levels, and the detection of multiple liver metastases by ultrasound. Somatostatin receptor scintigraphy (SRS) failed to detect the primary lesion, as did upper and lower gastrointestinal (GI) tract endoscopy, bronchoscopy, total body CT, MRI, and GI video tract endoscopy; only F-DOPA PET-scan ascertained and accurately localized the primary ileal tumor. Surgery confirmed the localisation, and pathology revealed a 3 cm highly differentiated carcinoid tumor with low proliferation grade (Ki67<2). The therapy with short and long acting somatostatin analogues was started before surgery and continued after surgical intervention. There was a regression of the clinical carcinoid syndrome and a numerical involution of liver metastases, but the levels of chromogranin A and serotonin remained elevated. Other therapeutical option should be discussed.
- Subjects
CARCINOID; ENDOSCOPIC surgery; CHROMOGRANINS; SOMATOSTATIN; GASTROINTESTINAL hormones; PREVENTIVE medicine; ENTEROCLYSIS; REGRESSION analysis; MEDICAL imaging systems
- Publication
Acta Endocrinologica (1841-0987), 2008, Vol 4, Issue 4, p447
- ISSN
1841-0987
- Publication type
Article
- DOI
10.4183/aeb.2008.447