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- Title
DRINKING WATER DISINFECTION BY-PRODUCTS - TRIHALOMETHANES EXPOSURES EFFECTS ON CONGENITAL ANOMALIES RISK.
- Authors
KAPUSTINSKIENĖ, Violeta
- Abstract
Congenital anomalies are the major cause of infant morbidity and mortality and throughout later life. Epidemiological studies have suggested that pregnant women exposed to water DBPs containing elevated THM concentrations may be at a greater risk for adverse pregnancy outcomes, including foetal growth and congenital anomalies, characterised by structural deformities. However, findings of the studies completed to date have been inconsistent. Etiological studies show that toxic chemical substances, unfavourable social and demographic factors affecting pregnant women may have impact on the fetus development. However, the biological mechanisms by which THMs may affect the congenital anomalies formation remain unclear. The objective of the research was to evaluate the effects of drinking water THMs exposure during pregnancy for major congenital anomalies risk. Our findings provide new data on pregnant women organism response to toxic substances formed in drinking water during disinfection by chlorine considering dose-response relationship. For the first time, controlling for the main confounding variables was evaluated dose-response relationship between the internal THMs dose and congenital anomalies risk. This study shows some evidence for a relationship between THM internal dose and risk of congenital anomalies. Particularly, increase of prenatal exposure to brominated THM during first pregnancy trimester might increase the risk of congenital heart and other congenital anomalies. This research provides additional insight into the etiological mechanisms of congenital anomalies and stimulates to apply appropriate means for congenital anomalies prevention. The results of this epidemiological study stress the need for appropriate policy and interventional programs aimed at reduction of adverse pregnancy outcomes.
- Subjects
DRINKING water purification; DISINFECTION by-product; TRIHALOMETHANES; HUMAN abnormalities; EPIDEMIOLOGICAL research; PREGNANCY complications
- Publication
Ekologija, 2013, Vol 59, Issue 4, pxiii
- ISSN
0235-7224
- Publication type
Article