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- Title
Synthesis and Evaluation of Chitosan-Vitamin C Complex.
- Authors
TIAN, X. L.; TIAN, D. F.; WANG, Z. Y.; MO, F. K.
- Abstract
Chitosan is a biocompatible, biodegradable and non-toxic polysaccharide polymer. It dissolves in water only if the pH is lower than 6.5. To extend its range of application, many water-soluble derivatives have therefore been prepared. In this research, chitosan-vitamin C complex was synthesized and characterized with Fourier transformed infrared spectroscopy, differential scanning calorimetry and 1H-NMR. The solubility of chitosan-vitamin C complex in distilled water was greatly improved. The ·O2 - scavenging activity of chitosan-vitamin C complex was compared with chitosan and vitamin C by measuring the auto-oxidation rate of pyrogallic acid. Results showed that the scavenging activity on ·O2 - by chitosan-vitamin C complex was stronger than that by CS. At low concentrations (<0.05 mg/ ml), the scavenging activity of chitosan-vitamin C complex was stronger than that of vitamin C, but after certain concentrations (>0.1mg/ml), its scavenging activity was lower than that of vitamin C.
- Subjects
CHITOSAN; VITAMIN C; BIOSYNTHESIS; PYROGALLIC acid; VISCOSITY; FOURIER transform infrared spectroscopy; CALORIMETRY
- Publication
Indian Journal of Pharmaceutical Sciences, 2009, Vol 71, Issue 4, p371
- ISSN
0250-474X
- Publication type
Article