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- Title
Safety and Immunogenicity of Live Attenuated and Inactivated Influenza Vaccines in Children With Cancer.
- Authors
Carr, Silvana; Allison, Kim J.; Van De Velde, Lee-Ann; Kelly Zhang; English, Elizabeth Y.; Iverson, Amy; Daw, Najat C.; Howard, Scott C.; Navid, Fariba; Rodriguez-Galindo, Carlos; Jie Yang; Adderson, Elisabeth E.; McCullers, Jonathan A.; Flynn, Patricia M.
- Abstract
Background. The safety and immunogenicity of live, attenuated influenza vaccine (LAIV) has not been compared to that of the standard trivalent inactivated vaccine (TIV) in children with cancer. Methods. Randomized study of LAIV versus TIV in children with cancer, age 2-21 years, vaccinated according to recommendations based on age and prior vaccination. Data on reactogenicity and other adverse events and blood and nasal swab samples were obtained following vaccination. Results. Fifty-five eligible subjects (mean age, 10.4 years) received vaccine (28 LAIV/27 TIV). Both vaccines were well tolerated. Rhinorrhea reported within 10 days of vaccination was similar in both groups (36% LAIV vs 33% TIV, P > .999). Ten LAIV recipients shed virus; the latest viral shedding was detected 7 days after vaccination. Immunogenicity data were available for 52 subjects, or 26 in each group. TIV induced significantly higher postvaccination geometric mean titers against influenza A viruses (P < .001), greater seroprotection against influenza A/H1N1 (P = .01), and greater seroconversion against A/H3N2 (P = .004), compared with LAIV. No differences after vaccination were observed against influenza B viruses. Conclusions. As expected, serum antibody response against influenza A strains were greater with TIV than with LAIV in children with cancer. Both vaccines were well tolerated, and prolonged viral shedding after LAIV was not detected.
- Subjects
INFLUENZA vaccines; CHILDHOOD cancer; MOLECULAR immune response; RADIO wave attenuation; VACCINATION complications; INFLUENZA A virus; DIAGNOSIS
- Publication
Journal of Infectious Diseases, 2011, Vol 204, Issue 10, p1475
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1093/infdis/jir561