We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Preoperative multimodality treatment for soft tissue sarcomas.
- Authors
Levine, Edward A.; Trippon, Mary; Das Gupta, Tapas K.; Levine, E A; Trippon, M; Das Gupta, T K
- Abstract
<bold>Background: </bold>Frequently, soft tissue sarcomas (STS) do not present until they are large, thus making local control difficult. Consequently, different methods of preoperative cytoreduction should be evaluated.<bold>Methods: </bold>This study evaluated a 10-day preoperative regimen of intraarterial doxorubicin (10 mg/m2/d), with concomitant radiation therapy (25 Gy), administered to 55 adult patients with either Stage T2 (n = 41) or distal Stage T1 (n = 14) STS. Seven of the tumors were low grade. All patients were treated by the Division of Surgical Oncology at the University of Illinois between 1978-1991.<bold>Results: </bold>This regimen was successful and obviated the need for amputation in 47 patients who underwent wide soft tissue excision, an initial limb-salvage rate of 87%. Complications related to the therapy occurred in 26% of patients, which resulted in additional operative procedures in 7%. The mean follow-up time was 94 months. The 5-year overall survival rate was 69%, with a disease-free survival rate of 51%. Local control was unsuccessful in 15% of the patients. Three additional patients required amputation for recurrent disease (n = 2) or complications of therapy (n = 1), resulting in an ultimate limb-salvage rate of 81%.<bold>Conclusions: </bold>The long-term results of this preoperative protocol for adults with limb-threatening STS appears to justify the utilization of a multimodality approach. This preoperative regimen was useful in minimizing limb loss in patients with limb-threatening STS. However, intraarterial doxorubicin administration is associated with significant morbidity, and its role in multimodality treatment of STS requires further clarification.
- Publication
Cancer (0008543X), 1993, Vol 71, Issue 11, p3685
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(19930601)71:11<3685::AID-CNCR2820711135>3.0.CO;2-6