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- Title
How to manage invasive procedures in children with haemophilia.
- Authors
Ljung, Rolf C. R.; Knobe, Karin
- Abstract
Invasive procedures can be performed safely in children with haemophilia due to the availability of factor VIII/ IX for patients without inhibitors. Most guidelines are based on the experiences in adults, but still there is no established consensus on the optimal factor levels or duration of replacement therapy for adults undergoing surgery. Few publications have focused on surgery in children with haemophilia. Children who have developed inhibitors to factor VIII/ IX have to be treated with bypassing agents and constitute a group at higher risk for bleeding complications during surgery. The aim of this review is to summarize the experiences and opinions in the literature on replacement treatment of children with haemophilia, with and without inhibitors, during and after surgery, with a focus on the most prevalent clinical situations.
- Subjects
BLOOD coagulation disorders; ENZYME inhibitors; HEMOPHILIA treatment; PHYSICIANS' assistants; SAND bypassing; GUIDELINES
- Publication
British Journal of Haematology, 2012, Vol 157, Issue 5, p519
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1111/j.1365-2141.2012.09089.x