We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Improving Mortality Prediction Using Biosocial Surveys.
- Authors
Noreen Goldman; Dana A. Glei; Yu-Hsuan Lin; Maxine Weinstein
- Abstract
The authors used data from a nationally representative survey of 933 adults aged 54 years or older (mean age = 66.2 years; standard deviation, 8.0) in Taiwan to explore whether mortality prediction at older ages is improved by the use of 3 clusters of biomarkers: 1) standard cardiovascular and metabolic risk factors; 2) markers of disease progression; and 3) nonclinical (neuroendocrine and immune) markers. They also evaluated the extent to which these biomarkers account for the female advantage in survival. Estimates from logistic regression models of the probability of dying between 2000 and 2006 (162 deaths; mean length of follow-up = 5.8 years) showed that inclusion of each of the 3 sets of markers significantly (P = 0.024, P = 0.002, and P = 0.003, respectively) improved discriminatory power in comparison with a base model that adjusted for demographic characteristics, smoking, and baseline health status. The set of disease progression markers and the set of nonclinical markers each provided more discriminatory power than standard risk factors. Most of the excess male mortality resulted from the men being more likely than women to smoke, but each of 3 markers related to disease progression or inflammation (albumin, neutrophils, and interleukin-6) explained more than 10% of excess male mortality.
- Subjects
TAIWAN; DEMOGRAPHIC surveys; BIOSOCIAL theory; MORTALITY; DISEASES in older people; CARDIOVASCULAR diseases in old age; LOGISTIC regression analysis; BIOMARKERS; INFLAMMATION; DISEASE risk factors
- Publication
American Journal of Epidemiology, 2009, Vol 169, Issue 6, p769
- ISSN
0002-9262
- Publication type
Article
- DOI
10.1093/aje/kwn389