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- Title
Stiff-man syndrome: A GABAergic autoimmune disorder with autoantigenic heterogeneity.
- Authors
Gorin, Dr F.; Baldwin, B.; Tait, R.; Pathak, R.; Seyal, M.; Mugnaini, E.
- Abstract
Autoantibodies that reacted with cell bodies and axon terminals of gamma-aminobutyric acid (GABA)ergic neurons were present in the serum and cerebrospinal fluid in a patient with stiff-man syndrome with type I diabetes. Immunoblot experiments using this patient's serum and cerebrospinal fluid did not corroborate an earlier observation that these autoantibodies are directed against the GABAergic cytosolic enzyme, L-glutamic acid decarboxylase. While L-glutamic acid decarboxylase autoantibodies may be associated with this syndrome, they do not appear to be easily demonstrated.
- Publication
Annals of Neurology, 1990, Vol 28, Issue 5, p711
- ISSN
0364-5134
- Publication type
Article
- DOI
10.1002/ana.410280518