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- Title
Bixin and annatto seeds extract reduces blood pressure of rats treated with hypercholesterolemic diet.
- Authors
Caligiorne, Sordaini Maria; de Farias Lelis, Deborah; de M. Jensen, Carlos Eduardo; Soeiro, Carina Miranda; Carvalho de Melo, Juliana; Santos, Robson A.; Campagnole-Santos, Maria José; Sousa Santos, Sergio Henrique
- Abstract
Aim: The present study aimed to evaluate the effect of the treatment with aqueous extract of annatto seed and isolated bixin on the blood pressure of rats treated with a hypercholesterolemic diet. Methods: Extracts of annatto seeds and isolated bixin were administered to 30 male Wistar rats that were divided into six groups (n = 5): standard diet + water, standard diet + annatto, standard diet + bixin, cholesterol diet + water, cholesterol diet + annatto, cholesterol diet + bixin. Body weight and blood pressure were measured. After the treatment period, the animals were sacrificed and blood samples were collected for the measurement of total cholesterol, HDL and triglycerides. The heart, liver and kidney were collected and weighted. Results: The plasma levels of cholesterol were increased in the animals fed a high-cholesterol diet. The blood pressure at the end of the treatment was decreased in the animals treated with bixin. The weight of the organs collected was decreased in the groups treated with the annatto extracts and bixin, as compared to its respective groups. Conclusion: According to the conditions applied in this study, bixin appears to be a potentially therapeutic compound to be used in the treatment of hypertension and hyperlipidemia.
- Subjects
BLOOD pressure; THERAPEUTICS; ACHIOTE; LABORATORY rats; HYPERCHOLESTEREMIA; CHOLESTEROL; BLOOD sampling
- Publication
Revista Portuguesa de Ciências do Desporto, 2017, Issue S3A, p78
- ISSN
1645-0523
- Publication type
Article
- DOI
10.5628/rpcd.17.S3A.78