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- Title
Chemical reprogramming of Caenorhabditis elegans germ cell fate.
- Authors
Morgan, Clinton T.; Myon-Hee Lee; Kimble, Judith
- Abstract
Small molecules can control cell fate in vivo and may allow directed induction of desired cell types, providing an attractive alternative to transplant-based approaches in regenerative medicine. We have chemically induced functional oocytes in Caenorhabditis elegans adults that otherwise produced only sperm. These findings suggest that chemical approaches to therapeutic cell reprogramming may be feasible and provide a powerful platform for analyzing molecular mechanisms of in vivo cell reprogramming.
- Subjects
CAENORHABDITIS elegans; RHABDITIDAE; GERM cells; EMBRYOLOGY; PREVENTIVE medicine
- Publication
Nature Chemical Biology, 2010, Vol 6, Issue 2, p102
- ISSN
1552-4450
- Publication type
Article
- DOI
10.1038/nchembio.282