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- Title
Discovery and characterization of novel jeilongviruses in wild rodents from Hubei, China.
- Authors
Gan, Min; Hu, Bing; Ding, Qingwen; Zhang, Nailou; Wei, Jinbo; Nie, Tao; Cai, Kun; Zheng, Zhenhua
- Abstract
The genus Jeilongvirus comprises non-segmented negative-stranded RNA viruses that are classified within the Paramyxoviridae family by phylogeny. Jeilongviruses are found in various reservoirs, including rodents and bats. Rodents are typical viral reservoirs with diverse spectra and zoonotic potential. Little is currently known about jeilongviruses in rodents from central China. The study utilized high-throughput and Sanger sequencing to obtain jeilongvirus genomes, including those of two novel strains (HBJZ120/CHN/2021 (17,468 nt) and HBJZ157/CHN/2021 (19,143 nt)) and three known viruses (HBXN18/CHN/2021 (19,212 nt), HBJZ10/CHN/2021 (19,700 nt), HBJM106/CHN/2021 (18,871 nt)), which were characterized by genome structure, identity matrix, and phylogenetic analysis. Jeilongviruses were classified into three subclades based on their topology, phylogeny, and hosts. Based on the amino acid sequence identities and phylogenetic analysis of the L protein, HBJZ120/CHN/2021 and HBJZ157/CHN/2021 were found to be strains rather than novel species. Additionally, according to specific polymerase chain reaction screening, the positive percentage of Beilong virus in Hubei was 6.38%, suggesting that Beilong virus, belonging to the Jeilongvirus genus, is likely to be widespread in wild rodents. The identification of novel strains further elucidated the genomic diversity of jeilongviruses. Additionally, the prevalence of jeilongviruses in Hubei, China, was profiled, establishing a foundation for the surveillance and early warning of emerging paramyxoviruses. Highlights: 1. Two novel jeilongvirus strains (HBJZ157/CHN/2021 and HBJZ120/CHN/2021) were discovered and characterized. 2. The prevalence of jeilongviruses in rodents from central China was investigated, revealing that the Beilong virus is widespread.
- Subjects
HUBEI Sheng (China); CHINA; AMINO acid sequence; RODENTS; POLYMERASE chain reaction; PARAMYXOVIRUSES
- Publication
Virology Journal, 2024, Vol 21, Issue 1, p1
- ISSN
1743-422X
- Publication type
Article
- DOI
10.1186/s12985-024-02417-8