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- Title
Gene expression analysis using DNA microarray in HK-2 human proximal tubular cells treated with cadmium.
- Authors
Lee, Jin-Yong; Tokumoto, Maki; Fujiwara, Yasuyuki; Satoh, Masahiko
- Abstract
We examined the alteration of gene expression in HK-2 human proximal tubular cells exposed to cadmium (Cd) using DNA microarray analysis. Cd increased the expression of 30 genes, including 7 genes coding for heat shock proteins, more than 2.0-fold and decreased the expression of 21 genes, including transcription-related genes, such as AP2B1, HOXA7, HOXA9 and TCEB2, less than 0.5-fold prior to the appearance of cytotoxicity in HK-2 cells.
- Subjects
GENE expression; DNA microarrays; KIDNEY tubules; KIDNEY cell culture; GENETIC code; GENETIC transcription; CELL-mediated cytotoxicity
- Publication
Journal of Toxicological Sciences, 2013, Vol 38, Issue 6, p959
- ISSN
0388-1350
- Publication type
Article
- DOI
10.2131/jts.38.959