We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Activation of the Nuclear Factor E2-Related Factor 2 Pathway by Novel Natural Products Halomadurones A-D and a Synthetic Analogue.
- Authors
Wyche, Thomas P.; Standiford, Miranda; Yanpeng Hou; Doug Braun; Johnson, Delinda A.; Johnson, Jeffrey A.; Bugni, Tim S.
- Abstract
Two novel chlorinated pyrones, halomadurones A and B, and two novel brominated analogues, halomadurones C and D, were isolated from a marine Actinomadura sp. cultivated from the ascidian Ecteinascidia turbinata. Additionally, a non-halogenated analogue, 2-methyl-6-((E)-3-methyl-1,3-hexadiene)-γ-pyrone, was synthesized to understand the role of the halogens for activity. Halomadurones C and D demonstrated potent nuclear factor E2-related factor antioxidant response element (Nrf2-ARE) activation, which is an important therapeutic approach for treatment of neurodegenerative diseases.
- Subjects
ACTINOMADURA; ANTIOXIDANTS; TREATMENT of neurodegeneration; HALOGENS; NOCARDIACEAE
- Publication
Marine Drugs, 2013, Vol 11, Issue 12, p5089
- ISSN
1660-3397
- Publication type
Article
- DOI
10.3390/md11125089