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- Title
Effect of Ozone Produced from Antibody-catalyzed Water Oxidation on Pathogenesis of Atherosclerosis.
- Authors
Ke-Jun Peng; Yu-Shan Huang; Li-Na An; Xiao-Qun Han; Jing-Ge Zhang; Qiu-Lin Wang; Jing Sun; Shu-Ren Wang
- Abstract
Recent studies have suggested that antibodies can catalyze the generation of unknown oxidants including hydrogen peroxide (H2O2) and ozone (O3) from singlet oxygen (1O2) and water. This study is aimed to detect the effect of antibody-catalyzed water oxidation on atherosclerosis. Our results showed that both H2O2 and O3 were produced in human leukemia THP-1 monocytes incubated with human immunoglobulin G and phorbol myristate acetate. In the THP-1 monocytes incubated with human immunoglobulin G, phorbol myristate acetate and low density lipoprotein, the intracellular total cholesterol, free cholesterol, cholesteryl ester and lipid peroxides clearly increased, and a larger number of foam cells were observed by oil red O staining. The accumulation of all intracellular lipids was significantly inhibited by vinylbenzoic acid, and only slightly affected by catalase. These findings suggested that the production of O3, rather than H2O2, might be involved in the pathogenesis of atherosclerosis through the antibody-catalyzed water oxidation pathway. Edited by Ming-Hua XU
- Subjects
IMMUNOGLOBULINS; HYDROGEN peroxide; OXIDIZING agents; ATHEROSCLEROSIS; IMMUNOGLOBULIN G; PHORBOLS
- Publication
Acta Biochimica et Biophysica Sinica, 2006, Vol 38, Issue 6, p417
- ISSN
1672-9145
- Publication type
Article
- DOI
10.1111/j.1745-7270.2006.00181.x