We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Antibiotics with antibiofilm activity - rifampicin and beyond.
- Authors
Ferreira, Luís; Pos, Ema; Nogueira, Daniela Rodrigues; Ferreira, Filipa Pinto; Sousa, Ricardo; Araújo Abreu, Miguel
- Abstract
The management of prosthetic joint infections is a complex and multilayered process that is additionally complicated by the formation of bacterial biofilm. Foreign material provides the ideal grounds for the development of an intricate matrix that hinders treatment and creates a difficult environment for antibiotics to act. Surgical intervention is often warranted but requires appropriate adjunctive therapy. Despite available guidelines, several aspects of antibiotic therapy with antibiofilm activity lack clear definition. Given the escalating challenges posed by antimicrobial resistance, extended treatment durations, and tolerance issues, it is essential to ensure that antimicrobials with antibiofilm activity are both potent and diverse. Evidence of biofilm-active drugs is highlighted, and alternatives to classical regimens are further discussed.
- Publication
Frontiers in Microbiology, 2024, p1
- ISSN
1664-302X
- Publication type
Article
- DOI
10.3389/fmicb.2024.1435720