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- Title
Sirt1: An Increasingly Interesting Molecule with a Potential Role in Bone Metabolism and Osteoporosis.
- Authors
Chen, Yi; Xiao, Hefang; Liu, Zirui; Teng, Fei; Yang, Ao; Geng, Bin; Sheng, Xiaoyun; Xia, Yayi
- Abstract
Osteoporosis (OP) is a common metabolic bone disease characterized by low bone mass, decreased bone mineral density, and degradation of bone tissue microarchitecture. However, our understanding of the mechanisms of bone remodeling and factors affecting bone mass remains incomplete. Sirtuin1 (SIRT1) is a nicotinamide adenine dinucleotide-dependent deacetylase that regulates a variety of cellular metabolisms, including inflammation, tumorigenesis, and bone metabolism. Recent studies have emphasized the important role of SIRT1 in bone homeostasis. This article reviews the role of SIRT1 in bone metabolism and OP and also discusses therapeutic strategies and future research directions for targeting SIRT1.
- Subjects
METABOLIC bone disorders; BONE metabolism; BONE density; BONE remodeling; NICOTINAMIDE; SIRTUINS
- Publication
Biomolecules (2218-273X), 2024, Vol 14, Issue 8, p970
- ISSN
2218-273X
- Publication type
Article
- DOI
10.3390/biom14080970