We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Chemical Composition Analysis and Assessment of Antioxidant and Anti-Inflammatory Activities of Crude Extract of Flueggea leucopyrus on Carrageenan-Induced Paw Edema in Wistar Albino Rats.
- Authors
Mayakrishnan, Vijayakumar; Thirupathi, Anand; Ramamoorthy, Kavitha; Annadurai, Kaliappan; Prakasam, Radha; Gu, Yaodong; Kim, Choon Young; Ramasamy, Mahadevi; Karimpanchola, Habeebmon; Kannappan, Priya; Vijayakumar, Natesan; Venkatesan Kumari, Bhuvaneshwari; Singaravelu, Anand
- Abstract
A member of the Phyllanthaceae family, Flueggea leucopyrus is a well-known plant in the tribal areas of Sri Lanka, India's Shaurastra region, Australia, and Malaysia. This study provides information about Flueggea leucopyrus, a plant with a wide range of therapeutic uses in India. Different extracts from the leaves and roots of Flueggea leucopyrus were evaluated for their physical and chemical properties, preliminary phytochemical parameters, and pharmacological activities in the current study, followed by their fourier transform infrared spectroscopy (FTIR), gas chromatography-mass spectrometry (GC–MS), antioxidant, and anti-inflammatory properties. The aqueous extract of Flueggea leucopyrus leaves and roots have more different phytochemical elements than other solvent extracts, according to physico-chemical tests and phytochemical screening. As a result, the FT-IR, GC–MS, antioxidant, and anti-inflammatory activities of an aqueous extract were tested. Studies on hind paw edemas caused by carrageenan in albino rats examined the mean increase in paw volume and the percentage inhibition in paw volume at various time points following the injection of carrageenan (1% w/v). In comparison to the norm, these inhibitions were statistically significant (p < 0.001). The aqueous extract of Flueggea leucopyrus leaves and roots have both antioxidative and anti-inflammatory activities, indicating that it has the potential to be used in the formulation of antioxidant and anti-inflammatory medications in the future.
- Subjects
FOURIER transform infrared spectroscopy; CHEMICAL properties; ANALYTICAL chemistry; LABORATORY rats; GAS chromatography/Mass spectrometry (GC-MS); ANTI-inflammatory agents
- Publication
Antioxidants, 2024, Vol 13, Issue 8, p976
- ISSN
2076-3921
- Publication type
Article
- DOI
10.3390/antiox13080976