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- Title
New Isoflavonoid and Anti-Inflammatory Constituents from Myristica elliptica var. simiarum.
- Authors
Kuo, Chu-Wen; Huang, Chien-Ming; Huang, Hsueh-Yang; Liang, Jia-Hua; Liaw, Chia-Ching; Sung, Ping-Jyun; Cheng, Ming-Jen; Chen, Zih-Rong; Chen, Jih-Jung
- Abstract
A new isoflavone, 4′-hydroxy-5,7,2′-trimethoxyisoflavone (1), has been isolated from the fruits of Myristica elliptica var. simiarum, together with seven known compounds, 2′-hydroxygenistein (2), licarin A (3), accuminatin (4), guaiacin (5), virolane (6), elimicin (7), and β-sitosterol (8). The structure of the new compound 1 was determined through spectroscopic and MS analyses. Among the isolated compounds, 4′-hydroxy-5,7,2′-trimethoxyisoflavone (1), 2′-hydroxygenistein (2), licarin A (3), and guaiacin (5) showed potent inhibition with IC50 values of 24.18 ± 2.09, 16.39 ± 1.26, 22.68 ± 2.30, and 27.01 ± 2.42 μM, respectively, against LPS-induced NO generation.
- Subjects
ANTI-inflammatory agents; FRUIT
- Publication
Chemistry of Natural Compounds, 2024, Vol 60, Issue 4, p615
- ISSN
0009-3130
- Publication type
Article
- DOI
10.1007/s10600-024-04396-2