We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Agrimonia coreana Extract Exerts Its Therapeutic Effect through CRAC Channel Inhibition for Atopic Dermatitis Treatment.
- Authors
Kim, Jintae; Lee, Ji Min; Park, Su Jin; Nam, Yu Ran; Choi, Seong Woo; Nam, Joo Hyun; Kim, Hyun Jong; Kim, Woo Kyung
- Abstract
Atopic dermatitis (AD) is a common allergic inflammatory skin condition marked by severe itching, skin lichenification, and chronic inflammation. AD results from a complex immune response, primarily driven by T lymphocytes and environmental triggers, leading to a disrupted epidermal barrier function. Traditional treatments, such as topical corticosteroids, have limitations due to long-term side effects, highlighting the need for safer alternatives. Here, we aimed to show that Agrimonia coreana extract (ACext) can be used in treating AD-related dermatologic symptoms. ACext could inhibit CRAC (Calcium Release-Activated Calcium) channel activity, reducing Orai1/CRAC currents and decreasing intracellular calcium signaling. This inhibition was further confirmed by the reduced IL-2 levels and T cell proliferation upon ACext treatment. In a mouse model of AD, ACext significantly ameliorates symptoms, improves histological parameters, and enhances skin barrier function, demonstrating its potential for treating AD.
- Subjects
ATOPIC dermatitis; INTRACELLULAR calcium; TREATMENT effectiveness; IMMUNE complexes; CELL proliferation; T cells
- Publication
International Journal of Molecular Sciences, 2024, Vol 25, Issue 16, p8894
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms25168894