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- Title
Oximes in organophosphorus poisoning.
- Authors
Cherian, M. A.; Roshini, C.; Peter, J. V.; Cherian, A. M.
- Abstract
Acute organic insecticide poisoning is a major health problem all over the world, particularly in the developing countries, where organophosphates (OPs) are the most common suicidal poisons with high morbidity and mortality and account for a large proportion of patients admitted to intensive care units. Other insecticides less commonly used are organocarbamates, organochlorides, and pyrethroids, which are less toxic and are associated with less morbidity and mortality. Patients with poisoning present with a wide spectrum of gastrointestinal, neurological, and cardiac manifestations. A strong clinical suspicion is necessary to make an early diagnosis and to start appropriate therapy. Treatment is primarily supportive and includes decontamination, anticholinergics, protection of the airway, and cardiac and respiratory support. The use of oximes has been controversial and may be associated with higher mortality owing to a higher incidence of type-II paralysis. They may have other toxic side effects. This paper reviews the literature on OP poisoning.
- Subjects
OXIMES; ORGANOPHOSPHORUS compounds; INSECTICIDES; PYRETHROIDS; DIAGNOSIS; CARDIOLOGICAL manifestations of general diseases; PARALYSIS
- Publication
Indian Journal of Critical Care Medicine, 2005, Vol 9, Issue 3, p155
- ISSN
0972-5229
- Publication type
Article
- DOI
10.4103/0972-5229.19682