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- Title
Dialysis-Chelex method for determination of exchangeable copper in human plasma.
- Authors
Venelinov, Tony I.; Davies, Ian M.; Beattie, John H.
- Abstract
A method based on dialysis in the presence of histidine, and subsequent copper adsorption and preconcentration using Chelex-100 resin, has been developed for selective extraction of exchangeable copper from blood plasma. The method was verified by comparative analysis using two different instrumental techniques, ICP-MS and AAS. The results obtained were in excellent agreement. Accurate quantification of the exchangeable copper and the firmly bound copper was achieved. The method was further validated by analysis of a lyophilised human serum certified reference material.
- Subjects
COPPER; BLOOD plasma; DIALYSIS (Chemistry); ADSORPTION (Chemistry); INDUCTIVELY coupled plasma spectrometry; TRACE analysis
- Publication
Analytical & Bioanalytical Chemistry, 2004, Vol 379, Issue 5/6, p777
- ISSN
1618-2642
- Publication type
Article
- DOI
10.1007/s00216-004-2529-x