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- Title
Cross‐Peaks in Simple Two‐Dimensional NMR Experiments from Chemical Exchange of Transverse Magnetisation.
- Authors
Waudby, Christopher A.; Frenkiel, Tom; Christodoulou, John
- Abstract
Two‐dimensional correlation measurements such as COSY, NOESY, HMQC, and HSQC experiments are central to small‐molecule and biomolecular NMR spectroscopy, and commonly form the basis of more complex experiments designed to study chemical exchange occurring during additional mixing periods. However, exchange occurring during chemical shift evolution periods can also influence the appearance of such spectra. While this is often exploited through one‐dimensional lineshape analysis ("dynamic NMR"), the analysis of exchange across multiple chemical shift evolution periods has received less attention. Here we report that chemical exchange‐induced cross‐peaks can arise in even the simplest two‐dimensional NMR experiments. These cross‐peaks can have highly distorted phases that contain rich information about the underlying exchange process. The quantitative analysis of such peaks, from a single 2D spectrum, can provide a highly accurate characterisation of underlying exchange processes.
- Subjects
NUCLEAR magnetic resonance spectroscopy; EXCHANGE reactions; MAGNETIZATION; SMALL molecules; CHEMICAL reactions
- Publication
Angewandte Chemie, 2019, Vol 131, Issue 26, p8876
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201903245