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- Title
Selective Ruthenium-Catalyzed Reductive Alkoxylation and Amination of Cyclic Imides.
- Authors
Cabrero ‐ Antonino, Jose R.; Sorribes, Iván; Junge, Kathrin; Beller, Matthias
- Abstract
Reported herein, for the first time, is the selective ruthenium-catalyzed reductive alkoxylation and amination of phthalimides/succinimides. Notably, this novel methodology avoids hydrogenation of the aromatic ring and allows methoxylation of substituted imides with good to excellent selectivity for one of the carbonyl groups. The reported method opens the door to the development of new processes for the selective synthesis of various functionalized N-heterocyclic compounds. As an example, intramolecular reductive couplings to afford tricyclic compounds are presented for the first time.
- Subjects
RUTHENIUM; ALKOXYLATION; AMINATION; IMIDES; AMINES
- Publication
Angewandte Chemie, 2016, Vol 128, Issue 1, p395
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201508575