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- Title
Hyperbranched Hybridization Chain Reaction for Triggered Signal Amplification and Concatenated Logic Circuits.
- Authors
Sai Bi; Min Chen; Xiaoqiang Jia; Ying Dong; Zonghua Wang
- Abstract
A hyper-branched hybridization chain reaction (HB-HCR) is presented herein, which consists of only six species that can metastably coexist until the introduction of an initiator DNA to trigger a cascade of hybridization events, leading to the self-sustained assembly of hyper-branched and nicked double-stranded DNA structures. The system can readily achieve ultrasensitive detection of target DNA. Moreover, the HB-HCR principle is successfully applied to construct three-input concatenated logic circuits with excellent specificity and extended to design a security-mimicking keypad lock system. Significantly, the HB-HCR-based keypad lock can alarm immediately if the "password" is incorrect. Overall, the proposed HB-HCR with high amplification efficiency is simple, homogeneous, fast, robust, and low-cost, and holds great promise in the development of biosensing, in the programmable assembly of DNA architectures, and in molecular logic operations.
- Subjects
NUCLEIC acid hybridization; ELECTRON-transfer catalysis; DNA; DNA structure; AMPLIFICATION reactions; DNA nanotechnology
- Publication
Angewandte Chemie, 2015, Vol 127, Issue 28, p8262
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/anie.201501457