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- Title
Multifunctional Nano-Bioprobes Based on Rattle-Structured Upconverting Luminescent Nanoparticles.
- Authors
Lu, Shan; Tu, Datao; Hu, Ping; Xu, Jin; Li, Renfu; Wang, Meng; Chen, Zhuo; Huang, Mingdong; Chen, Xueyuan
- Abstract
Lanthanide-doped upconversion nanoparticles (UCNPs) have shown great promise in versatile bioapplications. For the first time, organosilica-shelled β-NaLuF4:Gd/Yb/Er nanoprobes with a rattle structure have been designed for dual-modal imaging and photodynamic therapy (PDT). Benefiting from the unique rattle structure and aromatic framework, these nanoprobes are endowed with a high loading capacity and the disaggregation effect of photosensitizers. After loading of β-carboxyphthalocyanine zinc or rose Bengal into the nanoprobes, we achieved higher energy transfer efficiency from UCNPs to photosensitizers as compared to those with conventional core-shell structure or with pure-silica shell, which facilitates a large production of singlet oxygen and thus an enhanced PDT efficacy. We demonstrated the use of these nanoprobes in proof-of-concept X-ray computed tomography (CT) and UC imaging, thus revealing the great potential of this multifunctional material as an excellent nanoplatform for cancer theranostics.
- Subjects
RARE earth metals; NANOPARTICLES; PHOTODYNAMIC therapy; PHOTOSENSITIZERS; COMPUTED tomography; COMPANION diagnostics
- Publication
Angewandte Chemie, 2015, Vol 127, Issue 27, p8026
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201501468