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- Title
Lactoferrin prevents LPS-induced decrease of the iron exporter ferroportin in human monocytes/macrophages.
- Authors
Cutone, Antimo; Frioni, Alessandra; Berlutti, Francesca; Valenti, Piera; Musci, Giovanni; Bonaccorsi di Patti, Maria
- Abstract
Iron balance is tightly linked to inflammation and it has been demonstrated that many proteins involved in cellular iron management are up- or down-regulated by inflammatory stimuli, ultimately leading to iron retention in the reticuloendothelial system. Ferroportin is a key player in maintenance of correct iron homeostasis, because it is the only known mammalian cellular iron exporter. In this work we show that incubation of THP-1 monocytes/macrophages with lactoferrin prevents the LPS-induced decrease of ferroportin by reducing secretion of IL-6.
- Subjects
LACTOFERRIN; INFLAMMATION treatment; MONOCYTES; INTERLEUKIN-6; RETICULO-endothelial system infections; IRON; THERAPEUTICS
- Publication
BioMetals, 2014, Vol 27, Issue 5, p807
- ISSN
0966-0844
- Publication type
Article
- DOI
10.1007/s10534-014-9742-7