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- Title
Gastric-Type Expression Signature in Hepatocellular Carcinoma.
- Authors
Szodorai, Rita; Banias, Laura; Kovalszky, Ilona; Dezső, Katalin; Kovács, Zsolt; Gurzu, Simona
- Abstract
It is known that V-set and immunoglobulin domain containing 1 (VSIG1) is a cell–cell adhesion molecule that can serve as an indicator of better survival in patients with gastric cancer. Its interaction with cytoplasmic thyroid transcription factor 1 (TTF-1) has been hypothesized to characterize gastric-type HCC, but its clinical importance is far from understood. As VSIG1 has also been supposed to be involved in the epithelial–mesenchymal transition (EMT) phenomenon, we checked for the first time in the literature the supposed interaction between VSIG1, TTF-1, and Vimentin (VIM) in HCCs. Immunohistochemical (IHC) stains were performed on 217 paraffin-embedded tissue samples that included tumor cells and normal hepatocytes, which served as positive internal controls. VSIG1 positivity was seen in 113 cases (52.07%). In 71 out of 217 HCCs (32.71%), simultaneous positivity for VSIG1 and TTF-1 was seen, being more specific for G1/G2 carcinomas with a trabecular architecture and a longer OS (p = 0.004). A negative association with VIM was revealed (p < 0.0001). Scirrhous-type HCC proved negative for all three examined markers. The present paper validates the hypothesis of the existence of a gastric-type HCC, which shows a glandular-like architecture and is characterized by double positivity for VSIG1 and TTF-1, vimentin negativity, and a significant OS.
- Subjects
HEPATOCELLULAR carcinoma; TRANSCRIPTION factors; EPITHELIAL-mesenchymal transition; STOMACH cancer; INTERNAL auditing; VIMENTIN
- Publication
International Journal of Molecular Sciences, 2024, Vol 25, Issue 12, p6588
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms25126588