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- Title
Emerging evidence on the pathobiology of mucositis.
- Authors
Al-Dasooqi, Noor; Sonis, Stephen; Bowen, Joanne; Bateman, Emma; Blijlevens, Nicole; Gibson, Rachel; Logan, Richard; Nair, Raj; Stringer, Andrea; Yazbeck, Roger; Elad, Sharon; Lalla, Rajesh
- Abstract
Background: Considerable progress has been made in our understanding of the biological basis for cancer therapy-induced mucosal barrier injury (mucositis). The last formal review of the subject by MASCC/ISOO was published in 2007; consequently, an update is timely. Methods: Panel members reviewed the biomedical literature on mucositis pathobiology published between January 2005 and December 2011. Results: Recent research has provided data on the contribution of tissue structure changes, inflammation and microbiome changes to the development of mucositis. Additional research has focused on targeted therapy-induced toxicity, toxicity clustering and the investigation of genetic polymorphisms in toxicity prediction. This review paper summarizes the recent evidence on these aspects of mucositis pathobiology. Conclusion: The ultimate goal of mucositis researchers is to identify the most appropriate targets for therapeutic interventions and to be able to predict toxicity risk and personalize interventions to genetically suitable patients. Continuing research efforts are needed to further our understanding of mucositis pathobiology and the pharmacogenomics of toxicity.
- Subjects
ALIMENTARY canal cancer; PHARMACOGENOMICS; GENETIC polymorphisms; MUCOUS membrane diseases; INFLAMMATION; TISSUE physiology
- Publication
Supportive Care in Cancer, 2013, Vol 21, Issue 7, p2075
- ISSN
0941-4355
- Publication type
Article
- DOI
10.1007/s00520-013-1810-y