We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
2p24.1p23.2 deletion and delayed recovery after a general anesthesia for gastrointestinal endoscopic procedure.
- Authors
Dewé, Guillaume; Hermans, Emmanuel; Lavand'homme, Patricia; Polaner, David
- Abstract
Interstitial 2p deletions are very rare and may include proopiomelanocortin (POMC) gene (2p23.3). Our 10-year-old patient, known to carry this genetic anomaly, underwent an endoscopic interventional procedure under general anesthesia. After a sevoflurane induction, alfentanil (8.5 μg·kg−1) was given. The procedure lasted 22 min. There was an unexpected delayed recovery likely reflecting an unexpected delayed recovery likely due to opioid hypersensitivity. The deletion of POMC may cause a deficit in endorphin and may lead to an up-regulation of opioid receptors. Exogenous opioids should be used with particular caution in patients suffering a deficit of POMC.
- Subjects
GENERAL anesthesia; ENDOSCOPIC gastrointestinal surgery; GASTROINTESTINAL disease treatment; GENETIC disorders in children; OPIOIDS; DRUG side effects; DELAYED hypersensitivity
- Publication
Pediatric Anesthesia, 2017, Vol 27, Issue 6, p665
- ISSN
1155-5645
- Publication type
Article
- DOI
10.1111/pan.13095