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- Title
Myocardial microvascular function assessed by CMR first-pass perfusion in patients treated with chemotherapy for gynecologic malignancies.
- Authors
Yang, Meng-Xi; Li, Qing-Li; Wang, Dan-Qing; Ye, Lu; Li, Ke-Min; Lin, Xiao-Juan; Li, Xue-Sheng; Fu, Chuan; Ma, Xin-Mao; Guo, Ying-Kun; Yin, Ru-Tie; Yang, Zhi-Gang
- Abstract
<bold>Objectives: </bold>Cancer chemotherapy potentially increases the risk of myocardial ischemia. This study assessed myocardial microvascular function by cardiac magnetic resonance (CMR) first-pass perfusion in patients treated with chemotherapy for gynecologic malignancies.<bold>Methods: </bold>A total of 81 patients treated with chemotherapy for gynecologic malignancies and 39 healthy volunteers were prospectively enrolled and underwent CMR imaging. Among the patients, 32 completed CMR follow-up, with a median interval of 6 months. The CMR sequences comprised cardiac cine, rest first-pass perfusion, and late gadolinium enhancement.<bold>Results: </bold>There were no significant differences in the baseline characteristics between the patients and normal controls (all p > 0.05). Compared with the normal controls, the patients had a lower myocardial perfusion index (PI) (13.62 ± 2.01% vs. 12% (11 to 14%), p = 0.001) but demonstrated no significant variation with an increase in the number of chemotherapy cycles at follow-up (11.79 ± 2.36% vs. 11.19 ± 2.19%, p = 0.234). In multivariate analysis with adjustments for clinical confounders, a decrease in the PI was independently associated with chemotherapy treatment (β = - 0.362, p = 0.002) but had no correlation with the number of chemotherapy cycles (r = - 0.177, p = 0.053).<bold>Conclusion: </bold>Myocardial microvascular dysfunction was associated with chemotherapy treatment in patients with gynecologic malignancies, and can be assessed and monitored by rest CMR first-pass perfusion.<bold>Key Points: </bold>• Chemotherapy was associated with but did not aggravate myocardial microvascular dysfunction in patients with gynecologic malignancies. • Rest CMR first-pass perfusion is an ideal modality for assessing and monitoring alterations in myocardial microcirculation during chemotherapy treatment.
- Subjects
PREDICTIVE tests; CARDIOMYOPATHIES; NUCLEAR magnetic resonance spectroscopy; CONTRAST media; MAGNETIC resonance imaging; CHEMICAL elements; CORONARY circulation; PSYCHOLOGICAL tests; HEART function tests; RESEARCH funding; FEMALE reproductive organ tumors; PERFUSION
- Publication
European Radiology, 2022, Vol 32, Issue 10, p6850
- ISSN
0938-7994
- Publication type
journal article
- DOI
10.1007/s00330-022-08823-2