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- Title
Complications following ultrasound-guided core needle biopsy of thyroid nodules: a systematic review and meta-analysis.
- Authors
Ha, Eun Ju; Suh, Chong Hyun; Baek, Jung Hwan
- Abstract
<bold>Objectives: </bold>To identify the complication rate associated with US-guided core needle biopsy (CNB) of thyroid lesions using a systematic review and meta-analysis.<bold>Methods: </bold>Ovid-MEDLINE and EMBASE databases were searched for studies on US-guided CNB of thyroid lesions from 1 January 1994-13 December 2016. A review of 393 potential papers identified 39 eligible papers including 14,818 patients. The pooled proportions of complications were assessed using random-effects modelling. Subgroup analysis was performed. Among-study heterogeneity was explored using χ2 statistic for pooled estimates and inconsistency index I2. Quality of the studies was evaluated using the Risk of Bias Assessment Tool for Nonrandomized Studies.<bold>Results: </bold>The pooled proportion of overall complications after CNB of thyroid lesions was 1.11% (95% CI: 0.64-1.51, I2: 87.2%). The pooled proportion of major complications (0.06% [95% CI: 0.02-0.10], I2: 0.0%) was much lower than that of minor complications (1.08%[95% CI: 0.63-1.53], I2: 93.17%). Subgroup analysis revealed no significant differences between studies on Asian versus non-Asian groups (p=0.7769), radiologist versus non-radiologist groups (p=0.8607), nodule size <20 mm versus nodule size ≥20 mm (p=0.1591) groups, CNB versus CNB-plus-FNA groups (p=0.9281) and studies performed before and after 2012 (p=0.6251). The overall quality of the included studies was moderate with all of the studies satisfying five or more of the eight total domains.<bold>Conclusion: </bold>Various complications can occur after US-guided CNB of thyroid lesions. However, the procedure is safe, with a low complication rate.<bold>Key Points: </bold>• Various complications occurred after CNB of thyroid lesions, but the pooled complication rate was low (1.11%, I 2 = 87.2%). • The pooled proportion of major complications (0.06%) was much lower than that of minor complications (1.08%). • There was no significant differences between studies on Asian vs. non-Asian groups, radiologist vs. non-radiologist groups, nodule size <20 mm vs. nodule size ≥20 mm groups, CNB vs. CNB-plus-FNA groups, or studies performed before 2012 vs. after 2012.
- Subjects
NEEDLE biopsy; BIOPSY complications; MEDICAL radiology; RANDOM effects model; SYSTEMATIC reviews
- Publication
European Radiology, 2018, Vol 28, Issue 9, p3848
- ISSN
0938-7994
- Publication type
journal article
- DOI
10.1007/s00330-018-5367-5