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- Title
Feasibility of whole-body diffusion-weighted MRI for detection of primary tumour, nodal and distant metastases in women with cancer during pregnancy: a pilot study.
- Authors
Han, Sileny N.; Amant, Frédéric; Michielsen, Katrijn; De Keyzer, Frederik; Fieuws, Steffen; Van Calsteren, Kristel; Dresen, Raphaëla C.; Gziri, Mina Mhallem; Vandecaveye, Vincent
- Abstract
<bold>Objectives: </bold>To evaluate the feasibility of whole-body diffusion-weighted MRI (WB-DWI/MRI) for detecting primary tumour, nodal and distant metastases in pregnant women with cancer.<bold>Methods: </bold>Twenty pregnant patients underwent WB-DWI/MRI in additional to conventional imaging. Reproducibility of WB-DWI/MRI between two readers was evaluated using Cohen's κ statistics and accuracy was compared to conventional imaging for assessing primary tumour site, nodal and visceral metastases.<bold>Results: </bold>Both WB-DWI/MRI readers showed good-very good agreement for lesion detection (primary lesions: κ=1; lymph nodes: κ=0.89; distant metastases: κ=0.61). Eight (40 %) patients were upstaged after WB-DWI/MRI. For nodal metastases, WB-DWI/MRI showed 100 % (95 % CI: 83.2-100) sensitivity for both readers with specificity of 99.4 % (96.9-100) and 100 % (80.5-100) for readers 1 and 2, respectively. For distant metastases, WB-DWI/MRI showed 66.7 % (9.4-99.2) and 100 % (29.2-100) sensitivity and specificity of 94.1 % (71.3-99.9) and 100 % (80.5-100) for readers 1 and 2, respectively. Conventional imaging showed sensitivity of 50 % (27.2-72.8) and 33.3 % (0.8-90.6); specificity of 100 % (98-100) and 100 % (80.5-100), for nodal and distant metastases respectively.<bold>Conclusions: </bold>WB-DWI/MRI is feasible for single-step non-invasive staging of cancer during pregnancy with additional value for conventional imaging procedures.<bold>Key Points: </bold>• In our study, WB-DWI/MRI was more accurate than conventional imaging during pregnancy. • WB-DWI/MRI improves diagnostic assessment of patients with cancer during pregnancy. • Accurate imaging and oncologic staging improves treatment and outcome.
- Subjects
MAGNETIC resonance imaging; COMPUTED tomography; CERVICAL cancer; PREGNANCY complications; CANCER diagnosis; AGING; PERIPHERAL nervous system; RESEARCH evaluation; HUMAN research subjects
- Publication
European Radiology, 2018, Vol 28, Issue 5, p1862
- ISSN
0938-7994
- Publication type
journal article
- DOI
10.1007/s00330-017-5126-z