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- Title
Feasibility of measuring renal blood flow by phase-contrast magnetic resonance imaging in patients with autosomal dominant polycystic kidney disease.
- Authors
Spithoven, E.; Meijer, E.; Borns, C.; Boertien, W.; Gaillard, C.; Kappert, P.; Greuter, M.; Jagt, E.; Vart, P.; Jong, P.; Gansevoort, R.; Spithoven, E M; Boertien, W E; Gaillard, C A J M; Greuter, M J W; van der Jagt, E; de Jong, P E; Gansevoort, R T
- Abstract
<bold>Objectives: </bold>Renal blood flow (RBF) has been shown to predict disease progression in autosomal dominant polycystic kidney disease (ADPKD). We investigated the feasibility and accuracy of phase-contrast RBF by MRI (RBFMRI) in ADPKD patients with a wide range of estimated glomerular filtration rate (eGFR) values.<bold>Methods: </bold>First, we validated RBFMRI measurement using phantoms simulating renal artery hemodynamics. Thereafter, we investigated in a test-set of 21 patients intra- and inter-observer coefficient of variation of RBFMRI. After validation, we measured RBFMRI in a cohort of 91 patients and compared the variability explained by characteristics indicative for disease severity for RBFMRI and RBF measured by continuous hippuran infusion.<bold>Results: </bold>The correlation in flow measurement using phantoms by phase-contrast MRI was high and fluid collection was high (CCC=0.969). Technical problems that precluded RBFMRI measurement occurred predominantly in patients with a lower eGFR (34% vs. 16%). In subjects with higher eGFRs, variability in RBF explained by disease characteristics was similar for RBFMRI compared to RBFHip, whereas in subjects with lower eGFRs, this was significantly less for RBFMRI.<bold>Conclusions: </bold>Our study shows that RBF can be measured accurately in ADPKD patients by phase-contrast, but this technique may be less feasible in subjects with a lower eGFR.<bold>Key Points: </bold>Renal blood flow (RBF) can be accurately measured by phase-contrast MRI in ADPKD patients. RBF measured by phase-contrast is associated with ADPKD disease severity. RBF measurement by phase-contrast MRI may be less feasible in patients with an impaired eGFR.
- Subjects
KIDNEY physiology; BLOOD flow; BLOOD circulation; PHASE contrast magnetic resonance imaging; POLYCYSTIC kidney disease; RENAL artery physiology; BENZAMIDE; BLOOD pressure; COMPARATIVE studies; GLOMERULAR filtration rate; HEMODYNAMICS; LONGITUDINAL method; MAGNETIC resonance imaging; RESEARCH methodology; MEDICAL cooperation; IMAGING phantoms; RADIOPHARMACEUTICALS; RESEARCH; RESEARCH evaluation; RENAL circulation; PILOT projects; EVALUATION research; CONTRAST media; DISEASE progression; IODINE radioisotopes
- Publication
European Radiology, 2016, Vol 26, Issue 3, p683
- ISSN
0938-7994
- Publication type
journal article
- DOI
10.1007/s00330-015-3877-y