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- Title
Intravoxel incoherent motion diffusion-weighted imaging in the liver: comparison of mono-, bi- and tri-exponential modelling at 3.0-T.
- Authors
Cercueil, Jean-Pierre; Petit, Jean-Michel; Nougaret, Stéphanie; Soyer, Philippe; Fohlen, Audrey; Pierredon-Foulongne, Marie-Ange; Schembri, Valentina; Delhom, Elisabeth; Schmidt, Sabine; Denys, Alban; Aho, Serge; Guiu, Boris
- Abstract
Purpose: To determine whether a mono-, bi- or tri-exponential model best fits the intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI) signal of normal livers. Materials and methods: The pilot and validation studies were conducted in 38 and 36 patients with normal livers, respectively. The DWI sequence was performed using single-shot echoplanar imaging with 11 (pilot study) and 16 (validation study) b values. In each study, data from all patients were used to model the IVIM signal of normal liver. Diffusion coefficients (D ± standard deviations) and their fractions (f ± standard deviations) were determined from each model. The models were compared using the extra sum-of-squares test and information criteria. Results: The tri-exponential model provided a better fit than both the bi- and mono-exponential models. The tri-exponential IVIM model determined three diffusion compartments: a slow (D = 1.35 ± 0.03 × 10 mm/s; f = 72.7 ± 0.9 %), a fast (D = 26.50 ± 2.49 × 10 mm/s; f = 13.7 ± 0.6 %) and a very fast (D = 404.00 ± 43.7 × 10 mm/s; f = 13.5 ± 0.8 %) diffusion compartment [results from the validation study]. The very fast compartment contributed to the IVIM signal only for b values ≤15 s/mm Conclusion: The tri-exponential model provided the best fit for IVIM signal decay in the liver over the 0-800 s/mm range. In IVIM analysis of normal liver, a third very fast (pseudo)diffusion component might be relevant. Key Points: • For normal liver, tri-exponential IVIM model might be superior to bi-exponential • A very fast compartment (D = 404.00 ± 43.7 × 10 mm /s; f = 13.5 ± 0.8 %) is determined from the tri-exponential model • The compartment contributes to the IVIM signal only for b ≤ 15 s/mm
- Subjects
DIFFUSION magnetic resonance imaging; LIVER; PATIENTS; DIFFUSION coefficients; MAGNETIC resonance imaging
- Publication
European Radiology, 2015, Vol 25, Issue 6, p1541
- ISSN
0938-7994
- Publication type
Article
- DOI
10.1007/s00330-014-3554-6