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- Title
Optic radiation damage in multiple sclerosis is associated with visual dysfunction and retinal thinning--an ultrahigh-field MR pilot study.
- Authors
Sinnecker, Tim; Oberwahrenbrock, Timm; Metz, Imke; Zimmermann, Hanna; Pfueller, Caspar F; Harms, Lutz; Ruprecht, Klemens; Ramien, Caren; Hahn, Katrin; Brück, Wolfgang; Niendorf, Thoralf; Paul, Friedemann; Brandt, Alexander U; Dörr, Jan; Wuerfel, Jens
- Abstract
<bold>Objective: </bold>To investigate posterior visual pathway damage in multiple sclerosis using ultrahigh-field magnetic resonance imaging (MRI) at 7 Tesla (7 T), and to determine its correlation with visual disability and retinal fibre layer (RNFL) damage detectable by optic coherence tomography (OCT).<bold>Methods: </bold>We studied 7 T MRI, OCT, functional acuity contrast testing (FACT), and visually evoked potentials (VEP, n = 16) in 30 patients (including 26 relapsing-remitting MS and four clinically isolated syndrome patients) and 12 healthy controls to quantify RNFL thickness, optic radiation lesion volume, and optic radiation thickness.<bold>Results: </bold>Optic radiation lesion volume was associated with thinning of the optic radiation (p < 0.001), delayed VEP (p = 0.031), and visual disability indicated by FACT (p = 0.020). Furthermore, we observed an inverse correlation between optic radiation lesion volume and RNFL thickness (p < 0.001), including patients without previous optic neuritis (p < 0.001).<bold>Conclusions: </bold>Anterior visual pathway damage, but also (subclinical) optic radiation integrity loss detectable by 7 T MRI are common findings in MS that are mutually affected. Given the association between optic radiation damage, visual impairment, and increased VEP latency in this exploratory study of a limited sample size, clinicians should be aware of acute lesions within the optic radiation in patients with (bilateral) visual disturbances.<bold>Key Points: </bold>• Focal destruction of the optic radiation is detectable by 7 T MRI. • Focal optic radiation damage is common in MS. • Optic radiation damage is associated with RNFL thinning, detectable by OCT. • Optic radiation damage is associated with delayed VEP and visual dysfunction. • RNFL thickness in non-optic neuritis eyes correlates with optic radiation demyelination.
- Publication
European Radiology, 2015, Vol 25, Issue 1, p122
- ISSN
0938-7994
- Publication type
journal article
- DOI
10.1007/s00330-014-3358-8