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- Title
Squamous cell carcinoma of the head and neck: diffusion-weighted MR imaging for prediction and monitoring of treatment response.
- Authors
King AD; Mo FK; Yu KH; Yeung DK; Zhou H; Bhatia KS; Tse GM; Vlantis AC; Wong JK; Ahuja AT; King, Ann D; Mo, Frankie K F; Yu, Kwok-Hung; Yeung, David K W; Zhou, Hua; Bhatia, Kunwar S; Tse, Gary M K; Vlantis, Alexander C; Wong, Jeffrey K T; Ahuja, Anil T
- Abstract
<bold>Objective: </bold>To investigate the role of diffusion-weighted imaging (DWI) in predicting and monitoring chemoradiotherapy response in head and neck squamous cell carcinoma (HNSCC).<bold>Methods: </bold>Diffusion-weighted imaging was performed pre-treatment (n = 50), intra-treatment (n = 41) and post-treatment (n = 20). Apparent diffusion coefficient (ADC) values were correlated with locoregional failure (LF).<bold>Results: </bold>Locoregional failure occurred in 20/50 (40%) patients. A significant correlation was found between LF and post-treatment ADC (p = 0.02) but not pre- or intra-treatment ADC. Serial change in ADC was even more significant (p = 0.00001), using a fall in ADC early (pre- to intra-treatment) or late (intra- to post-treatment) to indicate LF, achieved 100% specificity, 80% sensitivity and 90% accuracy.<bold>Conclusions: </bold>Single ADC measurements pre- or intra-treatment did not predict response, but ADC post-treatment was a marker for LF. Serial change in ADC was an even stronger marker, when using an early or late treatment fall in ADC to identify LF.
- Publication
European Radiology, 2010, Vol 20, Issue 9, p2213
- ISSN
0938-7994
- Publication type
journal article
- DOI
10.1007/s00330-010-1769-8