We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Antimycobacterial Drugs and the Production of Reactive Oxidants by Polymorphonuclear Leucocytes in vitro.
- Authors
Zeis, B.M.
- Abstract
The effect of five antimycobacterial drugs isoniazid, rifampicin, streptomycin, pyrazinamide and ethambutol on the generation of reactive oxidants by polymorphonuclear leucocytes was investigated in vitro, using N-formyl-L-methionyl-L-leucyl-phenylalanine (FMLP) activated and spontaneous luminol-enhanced chemiluminescence and myeloperoxidase-mediated iodination. Streptomycin, pyrazinamide and ethambutol had no effect on the assays at the concentrations investigated. Isoniazid at concentrations of 1.25 and 5 μg/ml and rifampicin at 100 μg/ml significantly inhibited iodination. Rifampicin also caused dose-dependent inhibition of chemiluminescence, which was partly due to its light-absorbing activities. It is concluded that isoniazid, and to a lesser extent, rifampicin at therapeutic concentrations possess anti-oxidative properties. Copyright © 1988 S. Karger AG, Basel
- Publication
Chemotherapy (0009-3157), 1988, Vol 34, Issue 1, p56
- ISSN
0009-3157
- Publication type
Article
- DOI
10.1159/000238548