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- Title
Production of Amide Groups and Ammonia in the Radiolysis of Aqueous Solutions of Protein.
- Authors
BENNETT, WINIFRED; GARRISON, WARREN M.
- Abstract
RECENT studies in this Laboratory have indicated1,2 that a principal reaction in the radiolysis of aqueous solutions of protein under certain conditions involves cleavage of the peptide chain to form the carbonyl and amide functions as represented by the reaction: Evidence for this type of radiation-induced oxidation has been derived largely from studies of carbonyl production in oxygenated solutions of pepsin and gelatin. The carbonyl function is found to be associated with high molecular weight (non-dialysable) products which on conventional acid hydrolysis yield a series of α-keto acids. A correlation of these results in terms of a detailed mechanism for reaction (1) has been given elsewhere2.
- Publication
Nature, 1959, Vol 183, Issue 4665, p889
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/183889a0