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- Title
Synthesis of Substituted and Condensed Tetrahydrospiro[benzo-2-azepinecyclohexanes] from 1-Cyano- and 1-Carbamoyl-5-methyl-4,5-dihydro-3H-spiro[benzo-2-azepine-3,1′-cyclohexanes].
- Authors
Varlamov, A. V.; Grudinin, D. G.; Eganov, A. A.; Chernyshev, A. I.; Levov, A. N.
- Abstract
Substitution of the nitrile group by hydroxylamine and hydrazine has been effected in 1-cyanodihydrospiro[benzo-2-azepine-3,1′-cyclohexane]. From the 1-cyano and 1-hydrazino derivatives tetrahydrospiro{1,2,3- and 1,2,4-triazolo[5,1-a]benzoazepine-5,1′-cyclohexanes} have been obtained. It was established that 1-carbamoyldihydrospiro[benzo-2-azepine-3,1′-cyclohexanes] are converted under the conditions of the Hoffmann reaction into spiro{diaziridino[3,1-a]benzo-2-azepine-3,1′-cyclohexane{, and is reduced by sodium borohydride to the tetrahydro derivative.
- Subjects
ALICYCLIC compounds; CYCLOHEXANE; HETEROCYCLIC compounds; ORGANIC cyclic compounds; HYDRAZINE; HYDROXYLAMINE; TRIAZOLES
- Publication
Chemistry of Heterocyclic Compounds, 2005, Vol 41, Issue 7, p872
- ISSN
0009-3122
- Publication type
Article
- DOI
10.1007/s10593-005-0241-1