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- Title
Effects of cyclosporin A withdrawal on renal function and renal stimulation in liver transplant patients treated with triple-drug immunosuppression for over 2 years.
- Authors
Klompmaker, I. J.; van der Heide, J. J. Homan; Tegzess, A. M.; Meijer, S.; Haagsma, E. B.; Verwer, R.; Slooff, M. J. H.
- Abstract
The influence of CsA withdrawal on the glomerular filtration rate (GFR) and the effective renal plasma flow (ERPF) was prospectively studied in nine stable liver transplant recipients. Before CsA withdrawal (test 1), and 6 months thereafter (test 2) the renal function was determined by measuring GFR and the ERPF with I-iothalamate and I-hippuran respectively. The renal function was also stimulated with dopamine, with an amino-acid infusion and a combination of both. After CsA withdrawal the GFR increased, median from 74 ml min to 90 ml min, (<0.04). The ERPF also increased, median from 310 ml min to 380 ml min, (<0.03). In test 1 as well as in test 2 the renal function could be stimulated, especially with dopamine. GFR and ERPF improved, even after more than 2 years of CsA treatment. These results suggest that long-term CsA treatment impairs the renal function, though in these liver transplant patients CsA treatment did not prevent afferent and efferent arteriolar vasodilatation after renal stimulation. This reversible intrarenal vasoconstriction during CsA treatment may predict renal improvement after CsA withdrawal.
- Publication
Nephrology Dialysis Transplantation, 1994, Vol 9, Issue 11, p1629
- ISSN
0931-0509
- Publication type
Article