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- Title
A study of the β-lactamases of 100 clinical isolates of Yersinia enterocolitica.
- Authors
Pham, Jeannette N.; Bell, Sydney M.; Lanzarone, Josette Y. M.
- Abstract
The intracellular -lactamases of 100 distinct clinical isolates of were examined, to investigate the effect of selected -lactam agents on the enzymes. The enzyme inhibition profiles obtained were specific to each of the three biotypes 1A, 3 and 4. Biotype 4 strains elaborated only one -lactamase with a p of 8.3 corresponding to the carbenicillin-hydrolysing -lactamase enzyme A of Cornelis & Abraham. Biotype 3 strains also produced a single -lactamase with a pI of 5.4–5.6 corresponding to enzyme B, the chromosomally mediated inducible cephalosporinase. Two -lactamases were found in biotype 1A strains, one was identical to enzyme A and the other, although showing a slight difference in pI to enzyme B, was similar to this enzyme in other respects. The differences in the distribution of enzyme A and enzyme B in strains of Y. belonging to the biotypes 1A, 3 and 4 isolated in Australia, explain the different patterns of susceptibility to -lactam antibiotics.
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 1991, Vol 28, Issue 1, p19
- ISSN
0305-7453
- Publication type
Article