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- Title
Activity of ciprofloxacin against Mycobacteria in vitro: comparison of BACTEC and macrobroth dilution methods.
- Authors
Trimble, Kara A.; Clark, Richard B.; Sanders, W. Eugene; Frankel, Jack W.; Cacciatore, Robert; Valdez, Henry; Trimble, K A; Clark, R B; Sanders, W E Jr; Frankel, J W; Cacciatore, R; Valdez, H
- Abstract
Various clinical isolates of mycobacteria were tested for susceptibility to ciprofloxacin by a standard macrobroth dilution test and the radiometric BACTEC method. Agreement between the two test systems was species dependent: Mycobacterium tuberculosis (80%), M. kansasii with M. scrofulaceum (30%), M. avium-intracellulare (20%), and 0% for the rapidly growing mycobacteria. Most mycobacterial strains other than M. tuberculosis were susceptible to the breakpoint ciprofloxacin concentration of 2 mg/l as determined by BACTEC MICs, whereas none were susceptible by macrobroth testing. Seven of nine M. tuberculosis isolates were susceptible by either method. Ciprofloxacin merits further study as a potential antimycobacterial agent.
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 1987, Vol 19, Issue 5, p617
- ISSN
0305-7453
- Publication type
journal article