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- Title
The bioavailability for four different commerically available brands of ampicillin compared with that of talampicillin.
- Authors
Hamilton-Miller, J. M. T.; Brumfitt, W.; Hamilton-Miller, J M
- Abstract
A five-way crossover study in 10 volunteers was carried out to determine the bioavailability by the oral route of 4 brands of ampicillin and of talampicillin. There were no significant differences between the 4 ampicillins in terms of maximum serum levels, times of peak levels, serum concentrations at each sampling time, area-under-curves, half-lives and percentage urinary excretion (including peniciloate). A significantly higher proportion of the dose of ampicillin (65.6%) appeared in the urine after giving talampicillin than after giving any of the ampicillins (mean value = 38%). Thus, while there is no bioinequivalence amongst these ampicillin brands, talampicillin is a more effective way of delivering ampicillin. There were some indications that females absorb ampicillin less well than do males, and that there may be ‘good’ and ‘bad’ absorbers of ampicillin.
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 1979, Vol 5, Issue 6, p699
- ISSN
0305-7453
- Publication type
journal article