We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Successful treatment with tocilizumab monotherapy for Takayasu arteritis developing during infliximab therapy in a patient with ulcerative colitis.
- Authors
Shibata, Akiko; Kurasawa, Takahiko; Okada, Yusuke; Chino, Kentaro; Saito, Shuntaro; Okuyama, Ayumi; Takei, Hirofumi; Sakai, Ryota; Kondo, Tsuneo; Amano, Koichi
- Abstract
A 23-year-old female patient with ulcerative colitis (UC) who had been successfully treated with infliximab (IFX) plus 5-aminosalicylated acid (5-ASA) developed Takayasu arteritis (TAK). She refused to take glucocorticoids to treat TAK. IFX was discontinued, and 8 mg/kg of tocilizumab (TCZ) was added to 5-ASA. Her symptoms such as fever and chest pain disappeared within a week along with serum CRP. TCZ was administered every 2 weeks for 2 months and monthly thereafter. After 1-year treatment of TCZ monotherapy, arterial wall thickening also improved. In addition, UC has been in remission without any gastrointestinal symptoms. TCZ monotherapy is effective for TAK and might not compromise UC.
- Subjects
TOCILIZUMAB; INFLIXIMAB; ULCERATIVE colitis; GASTROINTESTINAL agents
- Publication
Modern Rheumatology Case Reports, 2018, Vol 2, Issue 2, p174
- ISSN
2472-5625
- Publication type
Case Study
- DOI
10.1080/24725625.2018.1479155