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- Title
Fibrillin I gene polymorphism is associated with tall stature of normal individuals.
- Authors
Mamada, Mitsukazu; Yorifuji, Tohru; Yorifuji, Junko; Kurokawa, Keiji; Kawai, Masahiko; Momoi, Toru; Nakahata, Tatsutoshi
- Abstract
In order to test the hypothesis that polymorphisms of the Marfan syndrome gene (FBN1) might affect the stature (height) of normal individuals, we genotyped three exonic SNPs on 428 males, 219 with tall stature (>2 SD) and 209 with normal stature (within ±1 SD). One of the SNPs, rs8033037, in exon 15 showed a significant correlation ( P = 0.0061) with the adult height, suggesting that FBN1 is one of the ‘stature genes’ of normal individuals.
- Subjects
MARFAN syndrome; STATURE; GENETIC polymorphisms; CONNECTIVE tissue diseases; GENETIC disorders; POPULATION genetics
- Publication
Human Genetics, 2006, Vol 120, Issue 5, p733
- ISSN
0340-6717
- Publication type
Article
- DOI
10.1007/s00439-006-0263-5